It was redesignated as the 25th Police Regiment in mid-1942 before it received the SS title in early 1943.

One of its early commanders was Gerret Korsemann, the chief of the Order Police in Lublin District from March 1940 through January 1941.

[2] The invasion of Russia in June 1941 created a need for rear-area security units on the Eastern Front and Police Regiment Lublin provided some of these.

[4] Together with the 22nd SS Police Regiment and other security forces, the regiment participated in Operation Harvest Festival (Aktion Erntefest) on 3–4 November, the massacre of 42,000 Jews imprisoned in the Majdanek extermination camp and several of its sub-camps.

During this time it was commanded by SS-Gruppenführer und Generalleutnant der Polizei Jakob Sporrenberg, SS and Police Leader (SS- und Polizeiführer) Lublin.