It was redesignated as the 22nd Police Regiment in mid-1942 before it received the SS title in early 1943.

[1] The invasion of Russia in June 1941 created a need for rear-area security units on the Eastern Front and Police Regiment Warsaw provided some of these.

They were partially replaced by worn-out units returning from Russia.

[2] The 22nd SS Police Regiment helped to crush the Warsaw Ghetto Uprising in April–May.

Together with the 25th SS Police Regiment and other security forces, the regiment participated in Operation Harvest Festival (Aktion Erntefest) on 3–4 November, the massacre of 42,000 Jews imprisoned in the Majdanek extermination camp and several of its sub-camps.