It was redesignated as the 21st Police Regiment in mid-1942 before it received the SS title in early 1943.

Police Regiment Moravia was created shortly after the occupation of Czechoslovakia in March 1939.

Assigned were four battalions numbered I through IV, although they were renumbered in the 200 series in October.

All of these units were transferred to Russia after Operation Barbarossa in June and were gradually replaced by various newly formed companies under the command of Reserve Police Battalion Holleschau.

In April, I Battalion became part of Police Rifle Regiment 34 (Polizei-Schützen-Regiment) and was later replaced by a newly formed unit.