The regiment fought at Georgia Landing, Fort Bisland, Irish Bend, and Brashear City in 1863 and Henderson's Hill and Mansfield in 1864.

Company D from Bienville Parish, originally titled the Du Lac Espagnol and led by Captain J. F. Scarborough, did not travel to Opelousas and was not incorporated into the new regiment.

[2] On 25 September 1862, elements of the 2nd Louisiana Cavalry encountered a small Federal force on Bayou Lafourche below Donaldsonville and compelled it to retreat to its gunboats.

On 27 October, the regiment fought in the Battle of Georgia Landing (Labadieville) and withdrew with other Confederate forces to Patterson on Bayou Teche.

Banks planned to have part of his army pin the Confederates at Fort Bisland while sending Brigadier General Cuvier Grover's division up the Atchafalaya in river transports to land at Grand Lake and cut off Taylor's retreat.

In the Battle of Irish Bend on 14 April, Taylor's soldiers blocked Grover's enveloping column and escaped Banks' intended trap.

The summer and fall were spent picketing along Bayou Teche and campaigning against Jayhawkers (pro-Union Louisianans) and Confederate deserters in the southwest part of the state.

The two forces proposed to join at Alexandria before heading upriver, supported by a gunboat fleet under Rear Admiral David Dixon Porter.

The 2nd Louisiana Cavalry was initially deployed near Vermilionville on Bayou Teche, except for three companies with Major General John George Walker's infantry division at Marksville.

[8] On 18 March, Taylor massed the divisions of Walker and Brigadier General Alfred Mouton at Carroll Jones' plantation, approximately midway between Alexandria and Natchitoches.

[10] Taylor reinforced Vincent's regiment with Captain William Edgar's 1st Texas Field Battery and sent it toward Alexandria, where it skirmished with the Federals for two days.

[11] Smith ordered Brigadier General Joseph A. Mower to take his infantry division and Colonel Thomas J. Lucas' cavalry brigade and probe to the north.

[12] Mower's force included the infantry brigades of Colonels Sylvester G. Hill and Lucius Frederick Hubbard, plus the 9th Indiana Battery.

Lucas' cavalry pushed the Confederates back to Henderson's Hill where Vincent formed a defensive line supported by Edgar's battery.

The Jayhawker then went to the Federal camp and divulged the countersign, allowing them to capture Vincent's pickets without raising an alarm.