The battery fought at Yorktown, Williamsburg, Seven Pines, Gaines' Mill, Glendale, Second Bull Run, Antietam, Shepherdstown and Fredericksburg in 1862.

[5] The Donaldsonville Artillery fought at the Battle of Williamsburg on 5 May, defending Fort Magruder with its 6-pounder guns at the end of the action.

On 1 June 1862, the battery played a minor role in the Battle of Seven Pines,[3] during which it was assigned to the artillery reserve of Longstreet's division.

[6] During the Seven Days Battles, Maurin's battery was assigned to Brigadier General Roger Atkinson Pryor's brigade in Longstreet's division.

Lee wanted to move upstream to his left in order to turn Pope's right flank, but first he needed to eliminate a Federal bridgehead downstream at Rappahannock Station.

Longstreet ordered a bombardment of the small bridgehead which was answered by Union batteries on the opposite bank; approximately 50 guns were involved in the artillery duel.

[15] While retreating cross-country from Union pursuit at night, the crew encountered an impassable woods; they abandoned and spiked the gun.

[16] At the Battle of Fredericksburg, the Donaldsonville Artillery remained part of Anderson's division, Longstreet's First Corps, Army of Northern Virginia.

[17] During the battle, the battery deployed on Marye's Heights protected by gun pits, and sustained a loss of 1 killed and 6 wounded.

[19][note 2] The Donaldsonville Artillery was not engaged at the Battle of Chancellorsville on 1–4 May 1863, according to Arthur W. Bergeron Jr.[18] However, the unit sustained a loss of 1 man wounded during the action.

[22] At Gettysburg, the unit was assigned to Garnett's battalion in Major General Henry Heth's division, Third Corps, Army of Northern Virginia.

[18] The Donaldsonville Artillery served during the Overland campaign, including the battles of the Wilderness (5–6 May 1864), Spotsylvania (9–21 May), and Cold Harbor (31 May–12 June).

[27] During the Appomattox campaign, Landry's battery was still assigned to Richardson's battalion, under the overall direction of Brigadier General Reuben Lindsay Walker in the Third Corps.