Shortly after the United States entered World War I, the regiment was constituted in the National Army on 18 May 1917, and organized on 17 February 1918 at Fort Ethan Allen.

Its designated mobilization training station was Fort Oglethorpe, and its primary ROTC feeder school was the University of Georgia.

[2] The regiment was disbanded on 18 October 1943,[1][2] after its personnel were called up for active duty during the military buildup prior to the American entry into World War II.

[5] The 310th was commanded by the following officers:[2] The 310th's coat of arms and distinctive unit insignia were approved on 23 September 1932, and both rescinded on 2 February 1959.

The regimental coat of arms was of a similar design to the distinctive unit insignia but included the Organized Reserve's Minuteman crest above the shield and omitted the motto.