Elements of the organization have been part of the United States Army Reserve since 1947 and participated in the Global War on Terrorism.

[2] Per the [National Defense Act of 1920]], the 378th Infantry was reconstituted in the Organized Reserve on 24 June 1921, assigned to the 95th Division, and allotted to the Eighth Corps Area.

[2] From the fall of 1944 until the end of the war in April 1945, the regiments of the 95th Division took part in several campaigns, including, Normandy, Northern France, Rhineland, Ardennes-Alsace, and Central Europe.

[2] Following the attacks of September 11, 2001, units of the 95th Division, including the 378th Regiment were ordered to active military duty as part of the Global War on Terrorism.

[2] The 378th Infantry Regiment's distinctive unit insignia (DUI) and coat of arms depict five wigwams, organized in rows of two, one, and two on a blue field.

[5] Blue represents the Infantry, and the five wigwams the Five Civilized Tribes of Oklahoma, where the regiment was organized— the Choctaw, Cherokee, Creek, Chickasaw, and Seminole.

[5] The regiment's motto, Hikia Kallo, appears on the DUI and is a Choctaw phrase that means “Stand Firm.”[5] The coat of arms of the 378th Infantry depicts the statue called The Lexington Minuteman that was sculpted by Henry Hudson Kitson.