4-Piperidone

4-Piperidone is an organic compound with the molecular formula OC(CH2)4NH.

4-Piperidone is used as an intermediate in the manufacture of chemicals and pharmaceutical drugs.

Substituted and dehydro derivatives of 4-piperidinone are intermediates in alkaloid syntheses.

[1] The N-protonated derivative is typically isolated as the hydrate (HO)2C(CH2)4NH+2.

[2] It is a List I chemical in the United States as it is a precursor to fentanyl.

NFPA 704 four-colored diamond Health 1: Exposure would cause irritation but only minor residual injury. E.g. turpentine Flammability 3: Liquids and solids that can be ignited under almost all ambient temperature conditions. Flash point between 23 and 38 °C (73 and 100 °F). E.g. gasoline Instability (yellow): no hazard code Special hazards (white): no code
Fentanyl synthesis using the Gupta method starting from 4-piperidone
Fentanyl synthesis using the Gupta method starting from 4-piperidone