The 1st Battalion, 114th Infantry took part in the Sinai Multi-National Force and Observers (MFO) Security Mission and was deployed for six months in 2004.

The brigade arrived at Belle Chase Naval Air Station and from there was forward deployed to the New Orleans Convention Center.

In 2006, and again in 2007, the brigade sent composite teams from across its component units as embedded trainers and advisors for the Afghan National Army.

In June 2008, 26 company-sized elements of the 50th IBCT were mobilized and trained at Fort Bliss, Texas, before being separately deployed to Iraq for the 2008–2009 rotation of Operation Iraqi Freedom (OIF).

The deployment of these 50th IBCT elements brought the total number of NJ National Guard Soldiers sent to Iraq and Afghanistan to over 3,200.

The units of the 50th Infantry Brigade Combat Team were welcomed home by family and friends with a parade through Trenton, NJ on 12 June 2009, after almost a year-long tour of Iraq.

The force structure of the Brigade was changed again in 2015, in accordance with the Army's latest Modified Table of Organization and Equipment (MTOE) for IBCTs.