It stars Kida Khodr Ramadan as Ali "Toni" Hamadi, the leader of a drug cartel in Berlin-Neukölln which has strong connections with the Arab crime families including his clan.
He brings in Vince Kerner, played by Frederick Lau, a boyhood friend, to restore order in the family business, much to the dislike of Toni's brother Abbas, played by Veysel, who is eager to succeed him as the family leader.
4 Blocks has received critical acclaim in Germany and has won multiple domestic awards, including the Grimme-Preis for Ramadan, Gelin, and director Marvin Kren, and six German Television Awards (Deutscher Fernsehpreis), including Best Drama Series, Best Actor for Ramadan, and Best Director for Kren.
The real boss, his uncle Ibrahim, has largely withdrawn from the business, but still gives the important orders in the background.
Toni, however, is dissatisfied with his role and wishes to be able to lead a life without crime with his wife Kalila and daughter Serin.
The situation becomes even more complicated when Vince meets Latif's wife Amara, for whom he already had a soft spot.
They leave his uncle badly injured, but Abbas kills the leader of the Hamadys in revenge for a reprimand he has received.
Vince tries to finalise his investigation and pushes for witness protection for him and Amara, who wants to elope with him.
He wants a strong Toni at the head of the Hamadys to prevent an open war, especially as he also realises that a megalomaniac Abbas is not the solution.
Vince manages to get hold of the gun Abbas used to shoot the policeman and passes it on to his colleagues.
When Mohammad's brother, who had previously served as a bargaining chip, dies in Lebanese prison, the Hamadys have no means of exerting pressure.
Information from him leads to the murder of Enis Haziri, known as "Potato", who is shot dead by Chechens during a courier trip.
The Hamadys demand an appeal, but in the meantime Abbas is being held in Tegel prison, which is under the control of the al-Saafis.
Toni, whose dispute with his brother remains unresolved, tries to get him out or at least have him transferred, while Abbas clashes with Frankie, who runs the prison's drug business.
Keil is furious and in his distress contacts Nico, a former member of the Cthulhus, who still has unfinished business with Toni.
However, Djamila gets wind of this and manages to tell Kalila about the murder plans, whereupon Toni executes Mohammad.
Kemal manages to save Toni from further shots and pursues the fleeing Nico while Kalila collapses.
A year later, Toni has largely withdrawn from the drug business and is volunteering to coach a football team in Neukölln made up of refugees.
The Berlin State Office of Criminal Investigation, with Alexandra Winter as the new head of the clan crime department, is also hot on the Hamadys' heels.
Fuelled by anonymous information from Zeki and a bugging operation in Abbas' house, Winter begins to increase the pressure on everyone involved.
But Winter wants the big fish, and instead of foiling the robbery, she lets herself be fooled by Abbas and only finds the empty suitcase.
When Abbas tries to kill Kemal, Toni is able to resolve the situation, but misses an important appointment to visit his daughter.
Meanwhile, Karami increases the pressure on Toni and has Latif shot just as he is about to reconcile with his wife for the sake of the children.
Toni tries to appease Karami with a picture of the dead Ewa and they apparently sever their business ties.
Finally, they set a trap for Karami on seemingly neutral territory and kill him and his henchmen.
Maruf, who has broken up with Zeki, is finally ordered to kill his old mate and shoots him under duress.
While the police unearth various hideouts of the Hamadys and presumably save the life of the seriously injured Zeki, Winter concentrates on the suspected diamond dealer.
While Winter savours her victory alone with rare champagne, the final scene shows Maruf sitting down at Latif's desk.
Locations in the Neukölln and Kreuzberg boroughs were used including the Sonnenallee, the Kottbusser Tor subway station and Görlitzer Park.