It was formed on May 16, 1806 during the reign of Tsar Alexander I of Russia and disbanded in 1918.

The regiment took part in warfare during the Napoleonic era, as well as World War I.

[1] The regiment was named after its patrons, various Prussian princes from 1822.

In 1914, its garrison was the Novogeorgievsk Fortress and it was part of the 1st Brigade of the 2nd Infantry Division (Russian Empire).

On 1 August 1914, the regiment dropped its patron's name from its title as a result of the outbreak of World War I against Germany.