The 6th Mississippi Infantry Regiment was a unit of the Confederate States Army that fought in many battles of the Western theater of the American Civil War.

[6] A monument to the 6th Mississippi was dedicated at Shiloh National Military Park in 2015, located at Rhea field where the troops of the Regiment fell in battle.

Bowen's brigade, including the 6th Regiment, was assigned to Major General Earl Van Dorn's corps and sent to fight at the Second Battle of Corinth in October.

The brigade then acted as Van Dorn's rear guard during the retreat from Corinth, and later returned to the Vicksburg area to prepare for the Union advance on the city.

"[8] At the Battle of Champion Hill on May 16, the Regiment engaged in skirmishes with Union troops,[2] and brigade commander General Tilghman was killed by artillery fire.

The Regiment was moved within the Vicksburg defensive lines during the siege of the city, where it was captured along with the rest of the Confederate garrison on July 4, 1863.

"[9] These men were Newton Knight's band of Unionist guerillas who had disrupted Confederate control of Jones County and the surrounding region.

The Confederate troops under Lowry fought skirmishes with the guerillas and summarily executed 9 of Knight's men by hanging.