Colonel James Hogun was appointed the regimental commander in November 1776.

The 7th Regiment was initially assigned to the Southern Department but in February 1777 the unit transferred to George Washington's main army.

In July 1777, the regiment was assigned to the North Carolina Brigade which was led by Francis Nash.

All the North Carolina regiments were badly understrength, with only two mustering over 200 men.

The regiment saw action at the battles of Brandywine and Germantown and it was present at White Marsh.