The Guilford County Regiment was authorized on September 9, 1775 by the Third North Carolina Provincial Congress.

The regiment was engaged in battles and skirmishes against the British and Cherokee during the American Revolution in North Carolina, South Carolina and Georgia between 1776 and 1781.

[1] It was first commanded by Colonel Ransom Sutherland, who was appointed by the North Carolina Provincial Congress.

Colonel Martin led the Guilford Militia at the Battle of Moore's Creek Bridge, at the Battle of Guilford Courthouse and in the Cherokee Expedition of 1776.

[2][3][1][4] Commandants and 2nd colonels:[1] Selected Captains (see Lewis for a complete list):[1] Elements of the Guilford County Militia participated in the following battles: See Engagements for a more complete list of engagements and comparison with other regiments in the Salisbury District Brigade.