When the rest of the army withdrew, Company F of the 8th Reserve, which had been sent forward as skirmishers, was not informed of the retreat and was left behind and captured by the Confederates.

It also fought at the battles of Charles City Cross Roads and Glendale, losing over 200 additional men.

At the Battle of Antietam, it fought on the Union right in the Cornfield, losing twelve killed and forty three wounded.

It played a part in the Union breakthrough on the Confederate right at the Battle of Fredericksburg but lost heavily, especially in officers.

One of the members of the regiment who continued to serve after the war, John A. Wiley, attained the rank of major general as commander of the 28th Infantry Division.