It is in the area of southwestern Pennsylvania that was claimed by Virginia, the District of West Augusta.

[3] It has a humid continental climate (Dfa/Dfb) and average monthly temperatures in Waynesburg range from 28.9 °F in January to 71.9 °F in July.

[4] Greene County is one of the 423 counties served by the Appalachian Regional Commission,[5] and it is identified as part of "Greater Appalachia" by Colin Woodard in his book American Nations: A History of the Eleven Rival Regional Cultures of North America.

[6] It is also located within the Laurel Highlands subrange, which consists of low plateaus and river valleys.

[11] Chart of Voter Registration Greene County is administered by a three-person board of commissioners, who serve four-year terms.

[13] Greene County's development commission has assisted area business since 1998.

Hill Top Energy Center, a natural gas-fired power plant with a generating capacity of 625 megawatts, is scheduled to begin operations in the summer of 2021.

[24] Some schools within the five above districts include: Greene County Airport is a county-owned, public-use airport located two nautical miles (4 km) east of the central business district of Waynesburg, Pennsylvania.

[28] Under Pennsylvania law, there are four types of incorporated municipalities: cities, boroughs, townships, and, in at most two cases, towns.

The following boroughs and townships are located in Greene County: Census-designated places are geographical areas designated by the U.S. Census Bureau for the purposes of compiling demographic data.