[2][3] The molecular mechanism of bone induction studied by Professor Reddi led to the conceptual advance in tissue engineering that morphogens in the form of metabologens bound to an insoluble extracellular matrix scaffolding act in collaboration to stimulate stem cells to form cartilage and bone.

[4][5][6] The Reddi laboratory has also made important discoveries unraveling the role of the extracellular matrix in bone and cartilage tissue regeneration and repair.

[12] Professor Reddi discovered that bone induction is a sequential multistep cascade involving chemotaxis, mitosis, and differentiation.

[15] They demonstrated first that BMPs bind the extracellular matrix,[16][17][18][19] are present at the apical ectodermal ridge in the developing limb bud,[20] are chemotactic for human monocytes,[21] and have neurotropic potential.

Reddi was also a student of Charles Brenton Huggins, the winner of the 1966 Nobel Prize with Peyton Rous for the endocrine regulation of cancer.