The A22 (Portuguese: Via do Infante de Sagres) is the principal motorway (freeway) in the Algarve, Portugal.

Named after Henry the Navigator, it connects Lagos to Castro Marim and connects to the A-49 Motorway (Spain) on the Guadiana International Bridge over the Guadiana River.

[1] It is also part of European route E01.

The A22 is operated by Euroscut Algarve.

Construction on A22 began in 1991 and was completed in 2003.