The road travels to a set of traffic lights, the turn off for the B5085 to Mobberley and Alderley Edge.

The road then heads towards Ollerton and Chelford, crossing the Crewe to Manchester branch of the West Coast Main Line and shortly after, there is a roundabout junction with the A535.

After this, the road goes to Monks Heath, where at a set of traffic lights, it crosses the A34.

After leaving Macclesfield, as Buxton New Road, the A537 continues its climb toward the Cat and Fiddle Inn.

The road is a mixture of some straight sections and some sharp, often blind bends, which are challenging to drivers and motorcyclists.