[4] As of 2024, AHF operates about 400 clinics, 69 outpatient healthcare centers, 62 pharmacies, and 22 Out of the Closet thrift stores across 16 U.S. states, Washington, D.C., Puerto Rico, and 47 countries, with over 5,000 employees, and provides care to more than 2.1 million patients.

[5][6][7][8][9] The organization's aim is to end the AIDS epidemic by ensuring access to quality healthcare, including HIV and STD testing, prescription of medications like Pre-exposure Prophylaxis (PrEP), and referrals to specialty pharmacies.

[18] In 1987, activists Chris Brownlie, Michael Weinstein, Sharon Raphael, PhD, Mina Meyer, MA, and other advocates were among the earliest champions of the AIDS hospice movement.

[23] On December 26, 1988, the 25-bed Chris Brownlie Hospice opened in the former nurses' dormitory at Barlow Respiratory Hospital and offered 24-hour medical and palliative care to people living through the final stages of AIDS.

[26][27][28] Located in South Central Los Angeles, MAP specifically focused on care for predominantly Black and Latino community members, accepting all terminal AIDS patients regardless if they had health insurance or not.

[22] He was survived by his longtime partner and Brownlie Hospice co-founder, Phill Wilson,[29] and his father, sister, brothers, countless friends and fellow AIDS activists.

96 cents of every dollar earned at the thrift stores goes to AHF's HIV/AIDS programs and housing services, on-site pharmacies, and free HIV testing.

[32] The first Out of the Closet thrift store opened in 1990 in Los Angeles' Atwater Village to benefit residents living with AIDS at the Chris Brownlie Hospice.

[34] In 1991, AHF opened the Richard Polanco HIV Clinic as a place where people in the early stages of AIDS could receive treatment even without private health insurance.

[42] A longtime float participant, the organization has earned a reputation for thought-provoking messages surrounding healthcare, homelessness, gay rights, anti-violence, and other issues.

[44] In August 2024, AHF opened a new all-in-one facility in Austin, Texas, including an HIV healthcare center, pharmacy services, STI testing and treatment, and an Out of the Closet thrift store, where 96 cents of every dollar earned goes back into local patient care.

[48] In the early 2000s, AHF developed a program called Global Immunity, whose goal is to change the course of the HIV/AIDS epidemic by expanding access to treatment for those living with HIV across the globe.

[56] In May 2023, AHF began a collaboration with the Pan American Health Organization (PAHO) to eliminate HIV/AIDS, tuberculosis, viral hepatitis, monkeypox, and other STIs in Latin America.

[61] They explain this as addressing gentrification and homelessness by promoting rent control and discouraging evictions; supporting sustainable land-use policies without disrupting neighborhoods; and creating affordable housing through cost-effective new construction and the adaptive reuse of existing buildings.

[67]: 1  AHF has argued against accusations about lingering maintenance problems in the organization's Skid Row residential buildings, blaming city officials for failing to permit planned upgrades.

[70] In December 2023, AHF purchased the Morrison Hotel, made famous by The Doors' 1970 album cover, with plans to convert the building into 111 units of affordable housing.

[71] The Doors drummer John Densmore and rock photographer Henry Diltz helped HHF make the announcement, with the hotel becoming the 15th affordable housing property owned and managed by the organization in Los Angeles.

[73] In December 2023, AHF hosted its World AIDS Day Concert at NRG Arena in Houston, Texas, featuring Janet Jackson, Debbie Allen, and Blair Underwood.

[75] The organization paid $110,000 to Kevin de León for consultancy work in the period after he won election to the Los Angeles City Council, but before he took office.

[86] The global clinical trial for PrEP found that usage did not lead to riskier sex, which was explained by the fact that condom use among gay men is generally low.

In response to the outbreak, AHF began lobbying in favor of laws requiring condom use by male actors during sex scenes in adult films.

[99] In 2010, AHF unsuccessfully sued the Los Angeles County government to compel its health department to mandate condom use in adult film productions.

[105] In August 2014, the AIDS Healthcare Foundation filed a formal complaint with Nevada OSHA,[106] against Cybernet Entertainment LLC, which does business as Kink.com and related spin-offs.

Health officials in affected departments filed responsive suits, arguing massive wastes would result in a transition or duplication of services.

[122] AHF spent $2.3 million sponsoring an initiative that requires the use of condoms in all vaginal and anal sex scenes in pornography productions filmed in Los Angeles County, California.

[126] AHF spent $19.5 million as the almost sole supporter of the California Drug Price Relief Act, (the opposition spent $110 million, making this the most expensive ballot measure to date across California and the United States) a statewide 2016 ballot initiative that would have revised California law to require state programs to pay no more for prescription medications than the prices negotiated by the United States Department of Veterans Affairs (notwithstanding any other provision of law and insofar as permissible under federal law), while exempting managed care programs funded through Medi-Cal.

"As we work to house patients in L.A., City Hall focuses on approving $3,500 apartments that sit empty," Weinstein wrote in a Los Angeles Times op-ed.

"[138][139] Those and other similar statements have led opponents to characterize Weinstein as a rich NIMBY who opposes development because it would add traffic to his commute and block the views from his office building, rather than because he cares about the plight of poor renters or people with HIV.

[144] The new law does not apply to buildings built within the prior 15 years, or to single-family homes (unless owned by corporations or institutional investors) and retains "vacancy decontrol," meaning that rents can increase to market rate between tenants.

[157] Proposition 33 is opposed by California state senator Toni Atkins, San Diego mayor Todd Gloria, and other local leaders.