He was named College Soccer News Second Team All-Freshman after helping Maryland win the National Championship in 2005.

He made his professional debut on March 22, 2009, in Galaxy's first game of the 2009 MLS season against D.C. United, playing the whole 90 minutes at left back in a 2–2 draw.

DeLaGarza picked up his first career assist on July 11, sending in a cross that Edson Buddle headed past the Chivas USA keeper to give the Galaxy a 1–0 win.

[7] He helped the Galaxy defense concede 31 fewer goals than in 2008 and set a club record for clean sheets in a season with 12.

DeLaGarza would make two appearances in the playoffs as the Galaxy would go onto reach MLS Cup, where they lost to Real Salt Lake.

[8] On May 1, 2010, DeLaGarza scored the then fourth fastest goal in club history when he rushed to the back post to tap in a pass from Buddle after 51 seconds.

[5] Despite missing DeLaGarza, the Galaxy managed to return to MLS Cup once again and defeated the Dynamo for the second straight year, this time by a score of 3–1.

DeLaGarza returned to action on October 24 in a 4–0 loss to Isidro Metapán in a CONCACAF Champions League group stage match.

He also came off the bench in both of the Galaxy's quarter final games with Real Salt Lake in the playoffs; however, LA lost 2–1 extra time.

[5] The first of his playoff assists came on November 9 in the second leg of the Western Conference semi-final match up with Real Salt Lake.

DeLaGarza sent in a cross that Landon Donovan headed past Nick Rimando in the 10th minute to open up the scoring.

[5] On September 4, DeLaGarza became just the fifth Galaxy players to make at least 200 MLS regular season appearances for the club, joining Landon Donovan, Cobi Jones, Kevin Hartman and Mauricio Cienfuegos.

[23] He started all but four games at right back for Houston, missing three in April with a quad injury and one due to yellow card accumulation.

The Dynamo had declined the option on his previous deal, opting to negotiate a lower salary as a result of his significant injury.

[25] DeLaGarza returned from injury on August 11 the Dynamo's USL affiliate, Rio Grande Valley FC in a 2–1 defeat to Sacramento Republic.

[26] His return was unable to save the Dynamo's season as they would miss the playoffs in 2018, the first time DeLaGarza's team had failed to qualify in his career.

He would make his first appearance of 2019 in the Dynamo's opening match of their CONCACAF Champions League campaign, a 1–0 win at Guastatoya on February 19.

After not appearing in the season opener due to being rested for the Champions League, DeLaGarza made 14 straight starts at right back in MLS matches, picking up one assist in that stretch.

[9] After appearing in his 23rd out of a possible 28 league games for the Dynamo, DeLaGarza's season came to an end on August 31 when he suffered a broken foot in a 1–0 loss to Sporting Kansas City.

[30] On December 2, 2019, DeLaGarza joined MLS expansion side Inter Miami CF ahead of their inaugural 2020 season.

[35] On November 17, 2022, DeLaGarza signed a ceremonial one-day contract with LA Galaxy and retired from playing professional soccer.

[36] In April 2024, DeLaGarza joined the Des Moines Menace ahead of the 2024 U.S. Open Cup second round match.

[39] On January 21, 2012, DeLaGarza made his début for the senior side of the United States in a friendly match against the Venezuela national football team.

[43] On June 11, 2015, DeLaGarza started and played all 90 minutes in Guam's first-ever World Cup Qualifier win beating Turkmenistan 1–0.

[44] Just a few days later DeLaGarza started and played all 90 minutes, against India, in Guam's second ever World Cup Qualifier win.

[48] DeLaGarza is married to Megan, his high school sweetheart, and the couple have another child, a daughter named Noelle born in October 2015.