959083397ENSG00000131016ENSMUSG00000038587Q02952Q9WTQ5NM_005100NM_144497NM_001370346NM_031185NP_005091NP_653080NP_001357275NP_112462A-kinase anchor protein 12, aka AKAP250, is an enzyme that in humans is encoded by the AKAP12 gene.

[5][6] The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell.

This protein and RII PKA colocalize at the cell periphery.

Antibodies to this protein can be produced by patients with myasthenia gravis.

Alternative splicing of this gene results in two transcript variants encoding different isoforms.