1HUR, 1RE0, 1U81, 3O47, 4HMY, 1R8Q, 1RRG, 1RRF37511840ENSG00000143761ENSMUSG00000048076P84077P84078NM_001658NM_001024226NM_001024227NM_001024228NM_001130408NM_007476NP_001019397NP_001019398NP_001019399NP_001649NP_001123880NP_031502ADP-ribosylation factor 1 is a protein that in humans is encoded by the ARF1 gene.

[5] ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family.

The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily.

The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport.

Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.