1DS639711857ENSG00000111348ENSMUSG00000030220P52566Q61599NM_001175NM_001321420NM_001321421NM_001321422NM_001321423NM_007486NP_001166NP_001308349NP_001308350NP_001308351NP_001308352NP_031512Rho GDP-dissociation inhibitor 2 is a protein that in humans is encoded by the ARHGDIB gene.

[17][18] Despite a high degree of sequence similarity, RhoGDI1 and RhoGDI2 are very different in their binding affinities for specific GTPases,[19] and more importantly, in their roles in tumor formation and spread of tumor to other organs (the process of metastasis).

While there are clear links between the alteration of RhoGDI2 protein levels and disease progression and/or metastasis in several types of cancer, the mechanistic underpinnings of the mode of RhoGDI2 action under carcinogenic cellular conditions are only now beginning to be understood.

Targeting this axis with orally available endothelin receptor antagonists[24] may prove efficacious in mimicking the inhibitory role of RhoGDI2 by preventing macrophage infiltration into the micrometastatic niche.

[25] Recent work has also determined that genetic and pharmacologic targeting of chemokine (C-C motif) ligand 2 (CCL2) also known as monocyte chemotactic protein-1 (MCP-1) or small inducible cytokine A2, its receptor CCR2 and pharmacologic ablation of macrophages can also phenocopy the effect of RhoGDI2 expression to prevent metastatic colonization of the lung67 and that RhoGDI2 is suppressor of versican, a protein that has been shown to promote cell migration[26] and metastasis in several tumor models.