2YSQ23229236915ENSG00000131089ENSMUSG00000025656O43307Q3UTH8NM_001353922NM_001353923NM_001353924NM_001353926NM_001353927NM_001353928NM_001369030NM_001369031NM_001369032NM_001369033NM_001369034NM_001369035NM_001369036NM_001369037NM_001369038NM_001369039NM_001369040NM_001369041NM_001369042NM_001369043NM_001369044NM_001369045NM_001033329NM_001290384NM_001290385NP_001340851NP_001340852NP_001340853NP_001340855NP_001340856NP_001340857NP_001355959NP_001355960NP_001355961NP_001355962NP_001355963NP_001355964NP_001355965NP_001355966NP_001355967NP_001355968NP_001355969NP_001355970NP_001355971NP_001355972NP_001355973NP_001355974NP_001392832NP_001392833NP_001392834NP_001392835NP_001392836NP_001392837NP_001392838NP_001392839NP_001392840NP_001392841NP_001392842NP_001392843NP_001392844NP_001392845NP_001392846NP_001392847Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ARHGEF9 gene.

[5][6][7] ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the inactive GDP-bound state.

These proteins are key regulators of the actin cytoskeleton and are involved in cell signaling.

[supplied by OMIM][7] ARHGEF9 has been shown to interact with GPHN[8] and SMURF1.

This article on a gene on the human X chromosome and/or its associated protein is a stub.