This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif.

It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally.

Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinositol-anchored to the erythrocyte membrane.

Allelic variants, some of which lead to adverse transfusion reactions, are known.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.