ASOS's headquarters are in Camden Town, at Greater London House, with additional offices in Berlin and Birmingham.

[9] The Danish company Bestseller A/S, owned by the business magnate Anders Holch Povlsen, is ASOS's largest stakeholder, with a 26% share.

[12] ASOS was established on 3 June 2000, by Nick Robertson,[8] Andrew Regan,[13] Quentin Griffiths, and Deborah Thorpe.

In November 2010, ASOS launched its marketplace platform for boutiques, vintage collectors, individuals and designers to trade from virtual market stalls to customers globally.

However, company spokespersons contended that the isolated complaints reported in the BuzzFeed article were not reflective of the general working conditions there.

[31] In April 2020, during the COVID-19 pandemic, ASOS was accused by some staff and workers unions of "playing Russian roulette with people’s lives" by failing to adequately enforce preventative measures in their Grimethorpe, Barnsley site.

[36][37] In October 2020, ASOS Marketplace announced that it would not be charging commission rates on small business transactions to provide support through the COVID-19 pandemic for sellers.

[38] In April 2021, ASOS has partnered with delivery company DPD of DPDgroup to allow shoppers the option to donate unwanted clothing to charity.

[40] In February 2021, it was announced that ASOS was to acquire the Topshop, Topman, Miss Selfridge, and HIIT brands from collapsed Philip Green's Arcadia Group.

[44][45] In January 2023 ASOS's share value UK dropped by 70% compared to the previous year, mainly due to online shopping and shipping of the products.

[48] The BBC reported that customers had reacted to the decision with anger with returns to Asos common due to the company's inconsistent sizing.