The club also competed in the UEFA Champions League, finishing as quarter-finalists, and the Coppa Italia, winning the trophy for the eighth time.

Other players such as Mirko Vučinić, Matteo Ferrari, Marco Cassetti and Ricardo Faty were signed to boost the squad.

During the winter transfer window, Vincenzo Montella was loaned to English club Fulham as he was lacking game time and wanted to try his luck in the Premier League.

In the first knockout round Roma were drawn against Lyon, who had already won 6 consecutive French championships and were the favourites to pass the round;[2] however, after a 0–0 draw at the Stadio Olimpico (with many controversial decisions by English referee Mike Riley, who yellow carded eleven players),[3] Roma won 2–0 in the Stade de Gerland with goals from Francesco Totti and Mancini, the latter of whom scored a sensational goal, performing a total of five stepovers in front of Lyon's dazed defender Anthony Réveillère.

Roma won the two final games with an aggregate result of 7–4; the first leg ended with a surprising 6–2 win while the second leg, though Inter's president Massimo Moratti claimed that they didn't care about the Coppa Italia,[5] was played with animosity and determination by the nerazzurri,[6] but the 2–1 final score gave the trophy to Roma.

Although the nerazzurri dominated the championship, they lost the match against 'giallorossi' 3–1 at San Siro, the same stadium in which Roma also beat the 2007 Champions League winner Milan 2–1, with two goals from Francesco Totti.