533114143ENSG00000117410ENSMUSG00000033379Q99437Q91V37NM_004047NM_001039457NM_001294333NM_033617NP_001034546NP_001281262NP_004038NP_291095V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

[5][6] This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.

V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation.

This encoded protein is part of the transmembrane V0 domain, and is the human counterpart of yeast VMA16.

Two alternatively spliced transcript variants that encode different proteins have been found for this gene.