A native of Las Vegas, Nevada, Blair threw a no-hitter in his sophomore year at Spring Valley High School.

During the summer between his sophomore and junior year, Blair played in the Cape Cod Baseball League for the Yarmouth-Dennis Red Sox.

[6] Included in his season was an 8 inning, 2 hit, 11 strikeout and no run game against the 19th ranked Houston Cougars in a 4–0 win to earn Blair Louisville Slugger National Pitcher of the Week.

Blair then became the highest drafted player in Marshall University baseball history when the Arizona Diamondbacks selected him in the 1st round with the 36th pick.

[11] He was promoted in August to the South Bend Silver Hawks of the Midwest League, where he won two playoff games.

[12] Blair made 12 more starts for Visalia before being promoted, this time to the Southern League with the AA Mobile BayBears.

Blair dominated in his first two Southern League starts, pitching a combined 13+2⁄3 innings, allowing 1 run and 8 hits while striking out 16 and walking 1.

Blair finished the 2014 season with Mobile with a 4–1 record in 8 starts, covering 46+1⁄3 innings with a 1.94 ERA to go along with 46 strikeouts.

[16] Blair ended his Reno stint with a record of 7–2 and an ERA of 3.16 in the hitting-friendly Pacific Coast League.

[17] On December 9, 2015, the Diamondbacks traded Blair, along with Dansby Swanson and Ender Inciarte, to the Atlanta Braves for Shelby Miller and Gabe Speier.

Blair did not play in a game for the Diamondbacks organization in 2020 due to the cancellation of the minor league season because of the COVID-19 pandemic.

[37] On April 12, 2022, Blair signed with the Wild Health Genomes of the Atlantic League of Professional Baseball.

[38] Blair struggled to an 0–4 record and 13.25 ERA across 7 starts for the Genomes, striking out 11 in 17.2 innings before he was released on June 23.