Grymes made his professional debut for the Edmonton Eskimos in 2013 and has also been a member of the Philadelphia Eagles of the National Football League (NFL) and BC Lions and Winnipeg Blue Bombers of the CFL.

[10] Following his NFL release, Grymes re-signed with the Eskimos and played in six games to finish the 2017 CFL season.

[16][17] On July 23, 2024, it was announced that Grymes had signed a practice roster agreement with the Winnipeg Blue Bombers.

[19] Grymes signed a one-day contract with the Edmonton Elks on September 6, 2024, in order to retire as a member of the team.

[20] On January 10, 2025, the Edmonton Elks announced that Grymes had been retained and was named the team's defensive backs coach.