[3][4] Ajayi began her career in the UK writing on television shows including EastEnders, Hollyoaks, and Casualty.
[5] In the US, Ajayi has worked as a writer-producer on Four Weddings and a Funeral, The First Lady,[6] Inventing Anna, and How to Get Away With Murder.
[9] In March 2023, Ajayi was featured in Variety's "International Women of Impact Report".
[10] Ajayi also writes fiction and she has been published in the literary magazine Callaloo.
[11] In 2021, Ajayi wrote and directed the drama series Riches for ITV and Amazon which began filming in 2021.