[4] In the 1990s, Hamdok held senior positions first at Deloitte & Touche and then at the International Labour Organization in Zimbabwe, followed by several years at the African Development Bank in Côte d'Ivoire.

[16][17] The Sovereignty Council of Sudan appointed Hamdok to be prime minister on 20 August, as required by the Draft Constitutional Declaration.

"[21] On 25 October 2021, the Sudanese military, headed by Abdel Fattah al-Burhan, arrested Hamdok and other senior government figures in a coup d'état.

The Ministry of Information declared that Hamdok was "still the legitimate transitional authority in the country" and called for the "immediate release of the prime minister and all detained officials".

The ministry also stated that "all unilateral measures and decisions taken by the military component lack any constitutional basis, violate the law, and are considered a crime.

[23] On 27 October, representatives of the European Union, Norway, Jordan, Libya, Somalia, Netherlands, Saudi Arabia, Israel, South Sudan, Haiti, Venezuela, Paraguay, Switzerland, the United States and the United Kingdom declared that their countries "continue to recognize the Prime Minister [Hamdok] and his cabinet as the constitutional leaders of the transitional government".

These countries also called for the end of a state of emergency, the release of political detainees, and "a genuine civil-military partnership" during the transition to elections.

[24] On 21 November 2021, Hamdok was reinstated as prime minister after a political agreement was signed by Sudan's top general Abdel Fattah al-Burhan to restore the transition to civilian rule.

However, the Forces of Freedom and Change (FFC) civilian coalition, which shared power with the military, and the Sudanese Professionals Association (SPA) both rejected the political deal.

[30] On 2 January 2022, Hamdok announced his resignation as prime minister in a televised speech, saying that the country was at a dangerous turning point[3] and roundtable discussion was needed to come to a new agreement for Sudan's political transition to democracy.

[34] Tagadum announced its dissolution on 10 February 2025,[35] with Hamdok forming a new body, known as the Civil Democratic Alliance of the Forces of the Revolution, the following day.

[46] In November 2019, the government of Sudan repealed all laws restricting women's freedom of dress, movement, association, work and study.

Hamdok praised women in a message published on social media, saying that the laws were "an instrument of exploitation, humiliation, violation, aggression on the rights of citizens.