Anderson signed with the Chicago Bears as an undrafted free agent in 2018 and spent three seasons with them before playing with several other NFL teams.

He grew up in nearby Galloway Township and attended Absegami High School.

Anderson went on to have a good enough season to catch the eye of Bucknell University coach Joe Susan.

Anderson disciplined his body and weight and went from 235 as a senior in high school to 300 pounds in his college career.

[2] In his junior season, Anderson started all 11 games on the defensive line for a third straight year.

In addition to being named All-Patriot League for the fourth time, he was named the 2017 Patriot League Defensive Player of the Year and NCAA FCS Collegiate Player of the Year by the Brooks-Irvine Memorial Football Club.

[4] Before the 2018 NFL draft, Anderson participated in private workouts with the San Francisco 49ers and Seattle Seahawks.

[12] Anderson made the 2019 Bears' final roster and played in his maiden NFL game in the season opener against the Green Bay Packers.

[13] He was waived on September 11 and moved to the practice squad to make room for tight end J. P. Holtz,[14][15] but was promoted to the active roster on September 23 to increase defensive line depth following Bilal Nichols' injury.

[18] In the third quarter of the Bears' 36–25 loss to the New Orleans Saints on October 20, 2019, Anderson recorded his first career NFL sack on Teddy Bridgewater.

[34] He was elevated to the active roster on December 18 ahead of a week 15 game against Baltimore Ravens.

[36] He was elevated to the active roster the third time on January 8, 2022, ahead of a Week 18 game against the Detroit Lions.

[56] Abdullah Anderson's cousin Austin Johnson plays currently for the Buffalo Bills.