[5] Abena Osei Asare attended Achimota Primary School and continue her secondary education at Wesley Girls High School-Cape-Coast (1995–97) where she read General Arts with elective subjects as Economics, Geography and Elective Mathematics.

[5] She proceeded to work as the assistant director in Facilities and Finance for the New York University, Accra in Ghana between the period of (2004 and 2007).

[11][12] Abena contested and won the New Patriotic Party parliamentary seat for Atiwa East Constituency in the Eastern Region of Ghana in 2012.

In 2017, at age 38, Abena was the youngest woman ever to be appointed to the Ministry of Finance and Economic Planning as a deputy minister.

She has also represented the Minister at various international conferences including the UN meetings on SDGs and ILO on labour issues.

In terms of Corporate Governance, She represented the Ministry of Finance as a Director on the following boards; ADB BANK, SSNIT, NHIA and GIADEC.