Abeotaxane

Abeotaxanes are a class of taxoid molecules with a core 5/7/6 type ring structure.

This structure varies from the 6/8/6 or 6/10/6-membered core ring found in conventional taxoids such as paclitaxel or docetaxel.

Taxanes are highly effective anti-cancer agents and are utilized as first and second-line therapy in the treatment of many solid-tumor cancers.

Since the FDA approval of paclitaxel in 1998, subsequent research has focused on the synthesis of new and improved taxanes to address the issues of multi-drug resistance and central nervous system bioavailability, as well as on improvement of the side effect profile.

[citation needed] Taxchinin A was the first naturally occurring rearranged taxoid identified as an 11(15→1)-abeotaxane.