Ablomin is a toxin present in the venom of the Japanese Mamushi snake, which blocks L-type voltage-gated calcium channels.
Ablomin shows great sequence homology with triflin (83.7%) and latisemin (61.5%), two other snake venom components of the CRISP family, which also target voltage-dependent calcium channels.
[1] Ablomin reduces potassium-induced contraction of smooth muscles, suggesting that it blocks L-type voltage-gated calcium channels.
[3] Ablomin affects high potassium-induced contraction of arterial smooth muscle in rat-tails in a concentration-dependent matter.
[1] Blocking other L-type voltage gated Ca2+ channels, for instance in the heart, may lead to arrhythmias and even cardiac arrest.