He served as Rosh Yeshiva and head of a Bet Din in that city, and lived in Jerusalem towards the end of his life.
When Rabbi Pardo moved to Ottoman Palestine in 1781, he requested of Pinso to attempt to print his books.
For this purpose Pinso travelled to Livorno, where he met Hida and the Rabbi of Ferrara Yaakov Moshe Ayash [he] (future Rishon LeZion).
He died on the 18th of Cheshvan 5580 (either November 5 of 6, 1820), and was buried in the Sephardic section on the Mount of Olives, near the tomb of his teacher Rabbi David Pardo.
He authored the book Shem Hadash, a commentary on Rabbi Eliezer ben Samuel's Yereim.
Penso was the author of Appe Zuṭre (Salonica, 1798), a work on the paschal laws, and of Tola'at Shani (ib.