Abrams Creek rises north of Round Hill and flows in a southeasterly direction through Winchester.

[3] According to the Geographic Names Information System, it has also been known historically as:[1] Abrams Creek rises approximately one-half mile north-northeast of Round Hill, in Frederick County and then flows generally east to join Opequon Creek approximately one mile east of Winchester.

[7] Abrams Creek drains 18.86 square miles (48.8 km2) of area, receives about 38.9 in/year of precipitation, has a wetness index of 443.80, and is about 16% forested.

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