Abrus sambiranensis is a plant in the legume family Fabaceae, native to Madagascar.

Abrus sambiranensis is endemic to Madagascar, where it is confined to Antsiranana and Mahajanga provinces in the north of the country.

It is found from sea level to 500 metres (1,600 ft) altitude.

Threats to the species include from soil erosion due to deforestation and from harvesting for use in traditional medicine.

Two subpopulations are present in Manongarivo Special Reserve where the species is conserved.