Acanthocalycium spiniflorum is a species of flowering plant in the cactus family Cactaceae from Argentina.

The 10 to 20 straight, needle-like spines are flexible, yellowish to brown and have a darker tip.

[2] Under its synonym Echinopsis spiniflora this plant has won the Royal Horticultural Society's Award of Garden Merit.

[3] Acanthocalycium spiniflorum is widespread in the Argentine provinces of Córdoba and San Luis at altitudes of 1000 to 1500 meters.

[4] The specific epithet spiniflorus is derived from the Latin words spina for 'sting' or 'thorn' and florus for '-flowered' and refers to the scales on the flower tube of the species.