Construction of the present building began in 1575 on the ruins of an earlier church which was declared the cathedral of the diocese of Acerno in 444 by Pope Leo I.
As a result of a reconstruction project in 1989 the building has been completely restored and reopened for worship.
[2] The interior, on a Latin cross floorplan, consists of a central nave and two side-aisles, a transept, an apse and a sacristy, as well as the usual service areas.
Because of the recent destruction no reliefs or decorative works are now to be seen, except for some 18th-century frescoes attributed to Leonardo Pallante and the high altar.
As for the building's exterior, the very plain west front has a principal central doorway between two smaller ones, above which are two windows to either side of a small central rose window beneath a simple Classical pediment containing an oculus.