Acerra Cathedral (Italian: Duomo di Acerra; Cattedrale di Santa Maria Assunta) is a Roman Catholic cathedral in the town of Acerra in Campania, southern Italy, dedicated to the Assumption of the Virgin Mary.

The present Neoclassical cathedral stands on the site of an Ancient Roman temple of Hercules.

It has a Latin cross ground plan, with a nave and two side aisles separated by piers, and a cupola.

The west front is Neo-classical, with eight large Ionic columns standing on a chessboard paving of alternating basalt and marble slabs.

The cathedral contains a number of works of art, of which the principal are: