The Ham test is a blood test used in the diagnosis of paroxysmal nocturnal hemoglobinuria (PNH).
Patient red blood cells (RBCs) are placed in mild acid; a positive result (increased RBC fragility) indicates PNH or congenital dyserythropoietic anemia.
[1][2] This is now an obsolete test for diagnosing PNH due to its low sensitivity and specificity.
[3] As one fourth of PNH cases progress to aplastic anemia, Ham's test is occasionally positive in AA.
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