[3] It resembles Acis nicaeensis, which has an overlapping distribution, but can be distinguished by several characters, including wider leaves, longer pedicels, and a larger distance between the stigma and the anthers.

[2] As of 2007[update], Acis fabrei was only known from four populations in the Vaucluse department in south-east France, around Mont Ventoux and the River Nesque.

Plants are found in eroded soils poor in organic matter, such as terra rossa, in rocky glades, grassy areas and under Quercus pubescens.

[5] The species occurs in a generally protected region of France; two populations are in an area with a management plan that includes Acis fabrei.

One threat is the natural and deliberate expansion of forests, which produces closed canopies and, where the trees are pines or cedars, more acid soils through the build-up of leaf litter.