The river Nesque (French: La Nesque) is a river in Provence (France).

It flows through Vaucluse department, between Vaucluse Mountains and plains of Comtat Venaissin.

A tributary of the Sorgue de Velleron, it is 53.2 km (33.1 mi) long.

[1] Its drainage basin is 401 km2 (155 sq mi).

[2]