The song was released on 11 May 2023, through Ace Entertainment and Sony Music Latin as the third single from Shakira's twelfth studio album, Las Mujeres Ya No Lloran (2024).

[4] Rumors began circulating about Shakira's next single being a collaboration with Manuel Turizo titled "Copa Vacía" but plans were scrapped in favor of releasing "Acróstico".

Colombian songwriter Keityn, who had previously co-written "Te Felicito" and "Monotonía" for Shakira's album, stated in an interview that the inspiration behind the song was the acrostics that her mother used to compose for him when he was a child.

[9] The singer explained in a Instagram story the meaning of working with her children during the negotiation period for the divorce of their parents:[10]"This year Milan has written songs that have made me tear up, and Sasha has dedicated hours playing the piano and discovering his voice.

"Los Angeles Times's writer Tommy Calle found that the lyrics "show hope, maternal love, unconditional support and overcoming pain, so you can find more words that appear in the song".

[11] Camila Osorio of El País compared "Acróstico" to "TQG" and previous Shakira's songs, writing that the singer does not evoke "anger, revenge, or heartbreak" but she is inspired by "a love letter to her two children" of apology for the sad and troubled time they experienced during the finalization of the divorce.