Its range extends from the Red Sea, Kenya and South Africa to India, Malaysia, Japan, Indonesia and Australia.

[1] Acropora millepora is a zooxanthellate species of coral and harbours symbiotic dinoflagellates in its tissues.

The larvae of Acropora millepora preferentially settle on vertical surfaces and on encrusting coralline algae.

Surprisingly, the choice of substrate for settlement was modified by the strain of symbiont present in the locality even though it had not yet infected the tissues.

[5] The main threat affecting Acropora millepora is the destruction of the coral reefs where it lives.