He is the founder and executive director of Neuroscape[1] and the David Dolby Distinguished Professor of Neurology, Physiology, and Psychiatry at University of California, San Francisco (UCSF).

[9] His doctoral research on plasticity of glutamate receptors in the hippocampus and implications for cognitive changes in normal aging earned him the 1997 Krieg Cortical Scholar Award.

[13] His research approach uses a combination of human neurophysiological tools, including functional magnetic resonance imaging (fMRI), electroencephalography (EEG) and transcranial stimulation (TES).

[15][16] Among his notable scientific contributions is showing that healthy older adults exhibit deficits in suppressing distractions and multitasking, which relates to their working memory abilities.

[20][21] Gazzaley's translational studies have explored how cognitive abilities may be enhanced via engagement with custom designed, closed-loop video games, neurofeedback and transcranial stimulation.

[22] In 2009 he designed a video game, NeuroRacer, which was shown to improve working memory and sustained attention in older adults in a study published as a September 2013 cover story in the journal Nature.

[1] With his team at Neuroscape, Gazzaley continues to advance the role of interactive experiences delivered through closed-loop video games to improve cognition; an approach he has coined Experiential Medicine.

[4] In 2016, Gazzaley co-founded Sensync, a company creating a sensory immersion vessel to offer a novel wellness treatment called the Deep Brain Massage.