UPHS and the Perelman School of Medicine at the University of Pennsylvania together comprise Penn Medicine, a clinical and research entity of the University of Pennsylvania.

The Chester County Hospital and Health System joined UPHS in 2013.

Princeton Health officially merged into UPHS in January 2018.

[5] Phoenixville Hospital was sold again by CHS to Tower Health in 2017.

[6] In 2020, University of Pennsylvania-Penn Presbyterian was ranked as the 15th best hospital in the United States by the U.S. News & World Report.